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cover of episode Is animal testing even needed anymore?

Is animal testing even needed anymore?

2025/6/4
logo of podcast On Point | Podcast

On Point | Podcast
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B
Birgit Gierschik
D
Donald Ingber
J
Jenny Tam
M
Martin Makary
N
Nicole Klein-Stroyer
R
Rand Paul
Topics
Rand Paul: 我认为FDA现代化法案2.0是结束药物动物试验的重要一步，它授权FDA接受过去50年开发的动物试验替代方案，例如计算机建模和干细胞研究。强制动物试验导致有希望的药物和疗法的批准速度减慢，现在是法律赶上科学的时候了。 Martin Makary: 我认为新技术有望取代一些常规动物试验，缩短审批流程，降低研发成本，从而降低美国人的药价。 Donald Ingber: 我认为FDA对审查包含替代模型数据的研究性新药申请持开放态度，并将优先考虑包含替代模型数据的申请，并提供加速审查和加快流程的激励措施。动物试验是科学、医学和药物开发业务的核心组成部分，但FDA主要关注毒性，而制药公司也在寻找疗效和新的靶点，这在很大程度上也是基于动物的。我相信人类替代方案将非常有价值，并且已经开始变得非常有价值。 Nicole Klein-Stroyer: 我认为NIH没有打算立即停止动物研究，因为动物研究现在仍然非常重要，并且在科学上是合理的。随着对基于人类生物学的综合系统的投资增加，对动物模型的依赖将减少。

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The 1938 law mandating animal testing for new drugs was challenged in 2022 with the FDA Modernization Act 2.0, which allows for alternatives like computer modeling and stem cell research. The FDA is phasing out animal testing for some therapies, aiming to accelerate approval processes and lower costs.
  • FDA Modernization Act 2.0 allows alternatives to animal testing
  • FDA is phasing out animal testing for some drugs and therapies
  • New technologies promise to replace routine animal testing, potentially reducing approval times and costs

Shownotes Transcript

Running tests on lab rats, mice and other species is an integral part of biomedical research. Now, some say artificial intelligence and other technologies could soon make the practice obsolete.