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cover of episode SCCM Pod-531: CRRT Fluid Strategies: What Clinicians Need to Know

SCCM Pod-531: CRRT Fluid Strategies: What Clinicians Need to Know

2024/12/26
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Raghavan Murugan
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Raghavan Murugan: CRRT 是危重症 AKI 患者 ICU 护理的重要组成部分,它提供了一种温和且持续的肾脏替代疗法,能够比其他肾脏替代疗法更精确地控制体液和电解质。CRRT 主要用于溶质控制和体液管理,可以帮助管理高钾血症、严重尿毒症和严重体液超负荷等情况,既能控制输入的液体,也能去除多余的液体。CRRT 更像我们正常的肾脏,持续工作,提供体液和电解质控制,并且在管理溶质和体液方面更灵活。CRRT 和间歇性血液透析应作为互补疗法用于 AKI 危重病人的管理,因为两者都未单独显示出改善预后的效果。在血流动力学不稳定的患者中,我们更倾向于早期使用 CRRT 进行溶质和容量管理;随着患者病情好转和血流动力学稳定,我们再将其转换为间歇性血液透析。CRRT 治疗中最大的体液管理挑战是如何去除患者体内多余的体液,因为大部分体液位于血管外间隙,去除这些体液具有挑战性,通常需要反复试验和临床经验。目前尚无经过严格评估的 CRRT 期间体液去除的有效方案或临床指南,但新的研究开始提供证据,例如使用血流动力学监测来指导体液去除。CRRT 体液去除率的调整应采取整体方法,考虑患者的体液状态(复苏、稳定或去加重阶段)、血流动力学稳定性以及其他临床指标,并根据预测体重进行剂量调整,避免过快去除体液。CRRT 中的体液去除是控制性低血容量的一种形式,会对心血管系统造成压力,因此需要关注净超滤率,以间接评估心血管压力。CRRT 体液去除的起始和停止时间取决于患者的整体体液平衡、肾功能恢复情况以及血流动力学稳定性,需要根据患者个体情况灵活调整。需要将 CRRT 的体液管理纳入 ICU 解放方案中,并结合个体化评估和治疗,制定更全面的体液管理目标和指标。 Ludwig Lin: 作为主持人,Ludwig Lin 主要负责引导话题,提出问题,并对 Raghavan Murugan 的观点进行总结和补充。他强调了关注净超滤率而非机器每小时去除量的重要性,以及根据患者体重和病情灵活调整 CRRT 治疗方案的必要性。他同时也表达了对未来研究方向的期待,希望有更多数据来指导 CRRT 的临床实践。

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This chapter introduces continuous renal replacement therapy (CRRT) as a vital ICU treatment for severe acute kidney injury (AKI). It highlights CRRT's advantages over other therapies, such as its gentle, continuous approach and precise fluid/electrolyte control. The discussion covers scenarios where CRRT is particularly beneficial, such as managing hyperkalemia, uremia, and fluid overload.
  • CRRT is crucial for AKI patients in the ICU, similar to ventilators for respiratory failure.
  • CRRT offers precise fluid and electrolyte control compared to other methods.
  • It's particularly useful for managing severe hyperkalemia, uremia, and fluid overload.
  • CRRT provides continuous therapy for both fluid management and electrolyte regulation, offering flexibility in managing solutes and fluids.

Shownotes Transcript

Host Ludwig Lin, MD, welcomes Raghavan Murugan, MD, MS, FRCP, FCCM, a professor and leading expert in critical care nephrology. They discuss the latest insights on fluid management strategies during continuous renal replacement therapy (CRRT), drawing from recent research and white papers. Dr. Murugan emphasizes the importance of updated education on CRRT fluid removal practices to enhance clinical outcomes and patient care in critical settings. This podcast is sponsored by Baxter Health.