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cover of episode Science’s Breakthrough of the Year, and psychedelic drugs, climate, and fusion technology updates

Science’s Breakthrough of the Year, and psychedelic drugs, climate, and fusion technology updates

2024/12/12
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Science Magazine Podcast

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D
Daniel Clery
G
Greg Miller
K
Kelly Servick
P
Paul Voosen
S
Sarah Crespi
Topics
Greg Miller: 本年度的科学突破是lenacapavir,这是一种新型的HIV预防药物,临床试验显示其疗效显著,为对抗HIV/AIDS疫情带来了新的希望。此外,JWST的观测结果也带来了新的宇宙学发现,对早期星系演化的理论提出了挑战。在对地球的研究中,发现了新的细胞器——硝基体,以及对板块构造的新理解。 Kelly Servick: 迷幻药治疗精神疾病的研究取得了一定的进展,但同时也面临着监管方面的挑战。例如,FDA拒绝批准Lycos Therapeutics公司将MDMA联合心理治疗用于治疗PTSD的申请。在阿尔茨海默病治疗方面,两种新的抗体药物获得了批准,但其疗效有限,且存在一些副作用。 Paul Voosen: 2023年和2024年都将是有记录以来最热的一年,这与气候变化以及厄尔尼诺现象有关。空气污染的减少也可能导致地球吸收更多热量。 Daniel Clery: 核聚变能源领域取得了一些进展,JET反应堆创造了新的能量产生纪录,但商业化应用仍面临挑战,氚的供应有限,ITER的建成时间也将比预期晚。英国正在推进其独立的核聚变项目。

Deep Dive

Key Insights

What is the main objective of the James Webb Space Telescope (JWST)?

JWST is designed to observe the early universe, looking back to less than a billion years after the Big Bang, approximately 13 billion years ago, to study the first galaxies and objects formed during that era.

Why were the unexpectedly bright galaxies discovered by JWST a surprise?

The galaxies were brighter and larger than expected, suggesting they evolved faster than current theories of galaxy formation predict, which challenges existing models of early universe evolution.

What is the nitroplast, and why is its discovery significant?

The nitroplast is a new organelle found in marine algae that fixes nitrogen, converting nitrogen gas into usable forms like ammonia. Its discovery is significant because it is the first nitrogen-fixing organelle found in eukaryotes, potentially offering insights into reducing the need for nitrogen fertilizers in agriculture.

How might the discovery of the nitroplast impact agriculture?

The discovery could lead to the development of crops that can fix their own nitrogen, reducing the need for synthetic fertilizers, which have significant environmental impacts.

What new insights did researchers gain about plate tectonics this year?

Researchers discovered that the mantle waves generated during rifting zones spread laterally, affecting continental plates far beyond the rift zones, which could explain the formation of high plateaus and the distribution of diamonds.

How does the new DNA analysis technique help understand ancient family relationships?

The technique compares the frequency and length of identical DNA sequences in ancient individuals to determine their degree of relatedness, providing insights into social structures and inheritance patterns in ancient societies.

What were the key findings of the lenacapavir clinical trials for HIV prevention?

Lenacapavir, an injectable drug given every six months, showed 100% efficacy in preventing HIV infections in a trial involving 5,000 adolescent girls and young women in Africa, and 99.9% efficacy in a more diverse population trial.

Why is lenacapavir considered a breakthrough in HIV prevention?

Lenacapavir offers a long-acting, six-month injection that simplifies HIV prevention, overcoming the challenges of daily oral pills, such as adherence issues and stigma, making it a promising tool in the fight against HIV.

What challenges did the psychedelic drug trials face in 2024?

The trials faced issues with blinding participants, data collection, and concerns about patient safety, including allegations of trial participants being pressured to underreport negative outcomes and incidents of abuse during therapy sessions.

What role did El Niño play in the record-breaking temperatures of 2023?

El Niño contributed to the record temperatures by boosting global temperatures, but the rapid onset and lingering effects were unusual, suggesting a complex interplay between natural climate patterns and human-driven warming.

What is the current status of ITER, the international fusion reactor project?

ITER, originally scheduled to be completed in 2025, is now expected to be finished in 2034, with initial power-producing experiments planned for 2039. The delay is partly due to challenges in securing the necessary fuel, tritium.

What is the UK's approach to fusion energy development?

The UK is pursuing a more ambitious timeline by building a prototype power-producing reactor that could connect to the grid by the 2040s, skipping the experimental phase seen in other projects like ITER.

Shownotes Transcript

First up this week, Breakthroughs Editor Greg Miller joins producer Meagan Cantwell to discuss Science’s 2024 Breakthrough of the Year). They also discuss some of the other scientific achievements that turned heads this year, from ancient DNA and autoimmune therapy, to precision pesticides, and the discovery of a new organelle.

 

Next, host Sarah Crespi is joined by news staffers to catch up on threads they’ve been following all year. First a bumpy road for certain medicines. Editor Kelly Servick discusses the regulatory hurdles for psychedelic drugs and immunotherapy treatments for Alzheimer’s disease. Then we hear from Staff Writer Paul Voosen about why scientists think this will be the hottest year on record. Finally, what happened with fusion power this year? Staff Writer Daniel Clery brings updates.

 

This week’s episode was produced with help from Podigy).

 

About the Science Podcast)

 

Authors: Sarah Crespi; Greg Miller; Meagan Cantwell; Kelly Servick; Daniel Clery; Paul Voosen