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cover of episode Conan The Bacterium's Superpower: Resisting Radiation

Conan The Bacterium's Superpower: Resisting Radiation

2024/12/13
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Short Wave

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Brian Hoffman
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Michael Daly
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Preeti Malani
T
Thomas Cujo
T
Tuoh Su
Topics
Jessica Young 和 Emily Kwong:报道了耐辐射奇球菌(Deinococcus radiodurans)的超强抗辐射能力,以及科学家对其机制研究的最新进展。他们介绍了该细菌的昵称"柯南细菌",并指出科学家们长期以来一直试图揭开其抗辐射能力的秘密,这对于太空探索和医学应用具有重要意义。 Brian Hoffman:通过研究发现,耐辐射奇球菌的抗辐射能力并非其细胞内成分(磷酸盐、锰和肽)简单叠加的结果,而是这些成分相互作用产生的协同效应,整体效应大于各部分之和。 Michael Daly:对耐辐射奇球菌抗辐射机制的深入了解,为开发增强抗辐射能力的药物(例如,用于宇航员)提供了可能性。 Jessica Young 和 Emily Kwong:讨论了美国社会中普遍存在的孤独感问题,特别关注老年人群体。他们引用了密歇根大学健康老龄化全国调查的数据,指出尽管疫情后孤独感有所下降,但仍有三分之一的老年人感到孤独,这可能被低估了。 Thomas Cujo:长期孤独感会对健康造成负面影响,增加患心血管疾病和痴呆症的风险。 Preeti Malani:建议将孤独视为一种可预防和治疗的健康问题,积极培养人际关系,例如参加社团活动、与他人建立联系等,有助于缓解孤独感。 Jessica Young 和 Emily Kwong:介绍了某些鱼类和蜥蜴能够再生内耳毛细胞,恢复听力,而哺乳动物则不能这一现象。他们解释说,这与基因增强子的开关状态有关。 Tuoh Su:成年哺乳动物无法再生听力,是因为其基因增强子处于关闭状态,而某些鱼类和蜥蜴的基因增强子处于开启状态。他认为,通过基因疗法,或许可以开启哺乳动物的基因增强子,从而实现听力再生。

Deep Dive

Key Insights

What is Conan the Bacterium and why is it famous?

Conan the Bacterium, formally known as Deinococcus radiodurans, is famous for its ability to survive extreme levels of radiation—thousands of times higher than what would kill a human. It was discovered in the 1950s and has been nicknamed for its resilience.

How much radiation can Conan the Bacterium withstand compared to humans?

Conan the Bacterium can withstand radiation doses thousands of times higher than what would kill a human.

What are the potential applications of Conan the Bacterium's radiation resistance?

Potential applications include protecting astronauts from radiation in space and developing medical treatments to enhance human radiation resistance, such as for long missions to Mars.

What are the key components suspected to contribute to Conan the Bacterium's radiation resistance?

The key components suspected to contribute to its radiation resistance are phosphate, manganese, and peptides within its cells.

What recent discovery explains how Conan the Bacterium's radiation resistance works?

Recent research revealed that when phosphate, manganese, and peptides combine, they form a complex that provides more radiation protection than each component individually. This breakthrough was published in the Proceedings of the National Academy of Sciences.

What percentage of older adults in the U.S. feel lonely at least some of the time?

33% of older adults in the U.S. feel lonely at least some of the time, according to the National Poll on Healthy Aging from the University of Michigan.

What are the health risks associated with chronic loneliness?

Chronic loneliness increases the risk of cardiovascular disease and dementia. A 2022 study found that it can make people three times more likely to develop dementia.

How can loneliness be addressed as a health problem?

Loneliness can be addressed by fostering human connections through community activities, medical interventions like hearing aids, and pairing older adults with teens to combat social isolation.

Why can some animals regenerate their hearing while humans cannot?

Some animals, like zebrafish and lizards, can regenerate their hearing by regenerating hair cells in their inner ears. Humans and other adult mammals cannot because the gene enhancers that allow supporting cells to act as understudies are closed.

What role do gene enhancers play in hearing regeneration?

Gene enhancers act as switches that can be open or closed. In animals that can regenerate hearing, these switches are open, allowing supporting cells to replace damaged hair cells. In adult mammals, including humans, these switches are closed, preventing regeneration.

Chapters
Deinococcus radiodurans, nicknamed Conan the Bacterium, resists radiation thousands of times higher than lethal doses for humans. Scientists discovered that a combination of phosphate, manganese, and peptides within its cells provides this unique radiation protection, exceeding the sum of their individual effects. This breakthrough could lead to innovations like radiation-resistant medication for astronauts.
  • Deinococcus radiodurans's extreme radiation resistance.
  • The synergistic effect of phosphate, manganese, and peptides.
  • Potential applications in astronaut protection and medicine.

Shownotes Transcript

In the 1950s, scientists exposed a tin of meat to a dose of radiation that they expected would kill all forms of life. But one organism defied the odds and lived: Conan The Bacterium. Turns out this microorganism, known to science as Deinococcus radiodurans, is capable of surviving extreme levels of radiation* — *thousands of times the amount that would kill a human. So what's Conan's secret?*Want more stories about the microbial world? Let us know by emailing us at [email protected])!*Learn more about sponsor message choices: podcastchoices.com/adchoices)NPR Privacy Policy)