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cover of episode The Ambitious Quest To Genetically Map All Known Vertebrates

The Ambitious Quest To Genetically Map All Known Vertebrates

2024/12/4
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Eric Jarvis
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John Hamilton
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John Hamilton:为了解人类和其他动物的差异以及动物间的差异,需要大量的基因组数据。 Eric Jarvis: "基因组方舟"项目旨在收集并保存地球上所有物种的基因密码,这具有重要的科学和保护意义。该项目将测序约7万个物种的基因组,以解答进化和生物学的基本问题,例如是什么让鸟类成为鸟类,哺乳动物成为哺乳动物等。此外,该项目也具有保护濒危物种的道德意义,因为可以记录其基因信息,甚至有助于拯救其种群。 Eric Jarvis: 他从研究舞蹈转向脑科学,再转向基因组学,始终对复杂行为的遗传学感兴趣。早期研究中,他依赖其他科学家提供的基因数据,但发现数据质量差,导致研究效率低下。早期鸟类基因组研究的经验教训是基因组数据的质量至关重要,这促使他参与并领导脊椎动物基因组项目,致力于生产高质量的基因组数据。高质量的基因组数据对于科学研究至关重要,不能仅仅追求数量。 Eric Jarvis: 选择鸭嘴兽作为早期研究对象是因为它代表了哺乳动物进化树基部的分支,有助于理解哺乳动物的起源。该项目有助于研究发声学习和语言的进化,通过比较不同物种的基因组,可以了解控制大脑解剖结构的基因机制。通过研究不同发声学习能力的物种的基因组,可以深入了解发声学习技能的遗传基础。发声学习能力与认知能力高度相关,许多被认为聪明的动物也具有发声学习能力。对基因组的深入理解可能有助于利用基因工程技术来增强或修复人类的发声沟通回路。 Eric Jarvis: 对人类独特性定义的重新思考,人类与其他物种在某些方面具有共同点。 John Hamilton: 到2024年底,脊椎动物基因组项目已经完成了其前260个物种的大约80%的测序工作,这足以开始解答一些基本问题,但要完全理解人类的独特性还需要更多的基因组数据。

Deep Dive

Key Insights

What is the goal of the Vertebrate Genomes Project?

The goal is to sequence the genomes of about 70,000 animal species to create a 'Genome Ark,' aiming to answer fundamental questions about evolution and biology, and to preserve genetic data of species on the verge of extinction.

Why is sequencing the genomes of endangered species important?

Sequencing these genomes allows scientists to capture genetic data before species go extinct, potentially aiding in conservation efforts to save endangered populations.

What is the significance of the platypus in the Vertebrate Genomes Project?

The platypus represents a unique branch of the mammalian family tree, being an egg-laying mammal. Its genome helps scientists understand the genetic differences between egg-laying and placental mammals, shedding light on the origins of mammals.

How does the Vertebrate Genomes Project relate to vocal learning research?

The project provides genomes of species capable of vocal learning, such as songbirds, dolphins, and bats, which helps researchers understand the genetic basis of vocal learning and its evolution across different species.

What are the ethical implications of genetic engineering in relation to vocal learning circuits?

Genetic engineering could potentially enhance or repair vocal communication circuits in humans, which raises ethical concerns about modifying brain circuits and the implications for human behavior and identity.

What is the current progress of the Vertebrate Genomes Project?

By late 2024, the project had completed about 80% of its first 260 species, providing enough data to start answering questions about what makes different animals unique.

Why is high-quality genome sequencing crucial for the project?

High-quality sequencing ensures accurate data, preventing errors that could delay research and waste resources. It allows for more reliable comparative analysis across species.

What is the 'vocal learning cognitive complex'?

It refers to the association between vocal learning and complex behaviors like problem-solving and rhythmic body movements, which often co-evolve in species perceived as intelligent.

Chapters
The human genome project's completion in 2003 opened doors to understanding human genetic makeup, but to truly differentiate humans from other animals, scientists need many more genomes. The Vertebrate Genomes Project aims to sequence about 70,000 species, including those on the verge of extinction, to understand evolution and biology.
  • Completion of the human genome map in 2003 marked a starting point, not an end.
  • The Vertebrate Genomes Project aims to sequence 70,000 species to compare genomes and understand evolutionary differences.
  • The project also serves as a way to preserve genetic information of endangered species before extinction.

Shownotes Transcript

The Vertebrate Genomes Project: It's an ambitious effort by an international group of scientists to create a "Genome Ark" by sequencing the genomes of about 70,000 animal species. The hope is that through all of this gene sequencing, scientists will be able to answer some basic but important questions like: What makes a bird, well, a bird? What makes a mammal a mammal? Plus, with so many species on the verge of extinction, can scientists record their genetic information before they go extinct – or better yet, maybe help save the population from going extinct? Guest host Jon Hamilton), one of our favorite science correspondents, talks to Erich Jarvis), the chair of this project, to learn what this ark of animal genomes could mean for our future – and why a platypus qualified for early boarding. Want to hear more animal stories? Let us know at [email protected]) — we read every email.Listen to every episode of Short Wave sponsor-free and support our work at NPR by signing up for Short Wave+ at* plus.npr.org/shortwave*)*.*Learn more about sponsor message choices: podcastchoices.com/adchoices)NPR Privacy Policy)