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cover of episode Inside the Dramatic Race to Decode the Human Genome

Inside the Dramatic Race to Decode the Human Genome

2025/6/26
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The Pulse
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People
A
Aldo DePabe
C
Craig Venter
D
David Housler
E
Ernst Hafen
F
Francis Collins
J
Jim Kent
L
Lauren Linton
Topics
Maiken Scott: 25年前，人类基因组计划启动，目标是绘制人类基因的详细地图，为理解生物学和医学奠定基础。 Bill Clinton: 我们今天庆祝的是完成了对整个人类基因组的首次调查。这是一张由超过20,000个基因组成的详细的人类基因蓝图，这些基因由超过30亿个碱基对组成，我们的DNA，是携带我们身体如何发展和运作的代码的基本构建块。毫无疑问，这是人类有史以来制作的最重要、最奇妙的地图。 Francis Collins: 你必须认识到，基因组是你想要了解的关于生物学和医学的一切的中心。我对人类基因组计划非常支持，因为它是生物学和医学研究的核心。在对人类基因组有基本了解之前，很难想象为成百上千种疾病寻找基因原因。我曾犹豫是否领导人类基因组计划，但最终意识到这项研究的潜在重要性，不能因为时间不方便而放弃。

Deep Dive

Chapters
This chapter recounts the beginning of the Human Genome Project, highlighting its ambitious goal of mapping the human genome and the challenges faced by its leader, Francis Collins. It emphasizes the monumental task and the international collaboration involved.
  • Announcement of the first survey of the human genome in 2000
  • Francis Collins's leadership of the Human Genome Project
  • The project's initial 15-year timeline
  • The unexpected challenges and pressures faced by Collins

Shownotes Transcript

Twenty-five years ago, President Bill Clinton announced a historic achievement: The completion of the first-ever survey of the human genome. The ceremony focused on the power of unity and collaboration — but, behind the scenes, the journey to this generational discovery had been marked by a bitter, cut-throat competition. We  look back at the race to decode the human genome — and who really won.