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cover of episode Viral dark matter

Viral dark matter

2024/8/21
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Unexplainable

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Nicola Twilley
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Nicola Twilley: 我认为噬菌体疗法是对抗日益严重的抗生素耐药性危机的一个很有前景的方法。抗生素耐药性感染每年导致数十万人死亡,这一数字还在不断上升,如果不采取措施,未来这一数字将会更加惊人。抗生素的过度使用和滥用导致细菌产生耐药性,使得许多感染难以治疗。噬菌体是一种攻击细菌的病毒,它们能够高效地杀死细菌,并且可以针对特定类型的细菌。虽然噬菌体疗法目前还处于早期阶段,但它为对抗抗生素耐药性提供了一种新的途径。 噬菌体疗法的工作原理是利用噬菌体的特异性来杀死致病细菌。噬菌体非常小,肉眼无法观察到,它们通过附着在细菌上并注入其基因组来攻击细菌,利用细菌自身的机制或自身的机制来复制自身,最终导致细菌细胞破裂。噬菌体在自然界中广泛存在,它们每天都在高效地杀死大量的细菌。 然而,噬菌体疗法也存在一些挑战。首先,噬菌体具有很强的特异性,这意味着必须找到针对特定细菌的噬菌体,这需要进行大量的筛选和测试。其次,噬菌体疗法目前仅限于紧急情况下使用,因为我们对噬菌体的了解还很有限,还不能广泛应用于临床。此外,有些噬菌体也可能具有危险性,有些噬菌体可以增加细菌的毒性。 尽管如此,我认为噬菌体疗法具有巨大的潜力,在未来,随着我们对噬菌体的了解不断深入,噬菌体疗法将会在对抗抗生素耐药性中发挥越来越重要的作用。我们应该加大对噬菌体研究的投入,以便更好地理解噬菌体的机制,开发出更安全有效的噬菌体疗法。

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Phages, viruses that kill bacteria, are being explored as a potential solution to the growing crisis of antibiotic resistance. They are abundant and efficient, but our understanding and application of them are limited.

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With antibiotic resistance on the rise, some scientists are turning to viruses as a medical tool. But we barely know anything about the bacteria-eating viruses all around us. (First published in 2021)

Guest: Nicola Twilley), host of Gastropod)

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