Day 8 | 12 Body Parts of Christmas
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Hi, I'm Raj Punjabi from HuffPost. And I'm Noah Michelson, also from HuffPost. And we're the hosts of Am I Doing It Wrong, a new podcast that explores the all-too-human anxieties we have about trying to get our lives right. Each week on the podcast, Raj and I pick a new topic that we want to understand better and bring a guest expert on to talk us through how to get it right.

And we're talking like legit, credible experts. Doctors, PhDs, all around superheroes. From HuckPost and Acast Studios, check out Am I Doing It Wrong? wherever you get your podcasts. Ho, ho, ho, ho, ho, ho, ho, ho, ho, ho, ho!

Merry Christmas, everybody. 12 days of Christmas, that's what we're doing. Yes, what day are we on? We are on day eight of the 12 days of Christmas. Welcome back.

It's been a hell of a journey. I do some really nice, great topics. Matt does some pretty depressive ones. But we are doing... I'll start the song and maybe that will tell us what we're doing. On the eighth day of Christmas, my true love gave to me eight B vitamins. Seven cervical vertebrae. Six extraocular muscles. Five layers of skin. Four...

Four heart chambers. Three middle ear bones. Two carotid arteries. And a spleen in a healthy body. Very good. Loving this. So we, nobody else is, we are doing today eight B vitamins. Eight. Eight of them. Is that how many there are? Yes. No, I just decided to take something that had 20 of them and just choose eight. That doesn't surprise me. That wouldn't surprise me with you. Fair point. No, there are eight B vitamins, which we sometimes call the B-complex vitamins.

Just so you know, Matt, and this is a word of warning for not just you but all the listeners, don't eat the yellow snow. Yes. Right? I saw you the other day with a snow cone and it was –

...completely fluorescent yellow. Yeah. And I said to you, oh, where did you get that ice cream from? And you just looked at me straight face and said, that's not ice cream. And then you just kept licking. And so I knew that you had been very recently taking a B vitamin complex...

which tends to give you quite fluorescent urine. Now, I'm not saying that that's what the snow cone was. No. But I'm saying just, you know, if you want to correlate the two together, that's entirely up to you, sickos. But a B vitamin can make your urine fluorescent. Yellowy, I'm Calblad. Yellowy orange.

Right. And this is generally due to probably predominantly riboflavin, which is B2 of the 8B vitamins. And what is... And maybe B6 as well, which is the pyridoxine. Why is it named that? Okay. So let's first talk about these 8B vitamins. You've got B1, which is thiamine, not fireman, thiamine.

B2, riboflavin. B3, niacin. B5, pantothenic acid. B6, pyridoxine. B7, biotin. B9, folic acid or folate. And B12, cobalamin. So these are – you can see that we've skipped a couple of Bs. That's because these Bs don't exist. Oh. Right? They probably did exist in the past and then they realised that they weren't vitamins because the definition of a vitamin –

Would you like to know? Yes, tell me. It's a micronutrient, which means we require it for our survival. Small amounts. And for health. In small amounts, but we cannot produce it ourselves. Right. So we must obtain these micronutrients, again in small doses, in our diet. We must get it through our foodstuffs.

Now, some of vitamins that we ingest are what we call fat-soluble, which means it can be stored in our fats. There's vitamin D, E, K, and A. Yeah, A, D, E, K. Did I miss one? Yes. A, D. Just say deca. Oh, you go the other way. Deca, D, E, K, A. That's how I remember it. That's how I tell my students to remember it. Deca are the fat-soluble ones.

They get stored in the fatty tissue, which means we can hold on to them for months to years. And then the water-soluble vitamins, which we can hold on to for a little while, but because they're water-soluble, if we have more than we need, we tend to just pee them out. Hence why when most people take a B vitamin complex within an hour, their urine is fluorescent yellow. Meaning they're really probably not using much of it. Yeah, and I think you also get polyurea.

Like you pee more? Probably. Because it's osmotic. A lot of these B vitamins are mixed with glucose too to make it palatable. Oh, really? Yeah. So you'll probably find in a lot of them that there's glucose as part of it. Now, let's just... By the way, vitamin comes from vital amine. Yes. Yes. Even though most vitamins don't have an amine group associated with it, but they thought they did.

Anyway, so let's have a chat about these B vitamins. So you've probably read, if you've ever taken a B vitamin complex, that it says on the packet, oh, this...

It promotes energy metabolism and supports brain and nervous system health, right? That tends to be the thing that it always says on the packages. That is broadly true. It's true in the sense that in order for the nervous system to work, it does need these vitamins. And in order for metabolism to work appropriately, it does need these vitamins. What it doesn't tell you is that by taking this vitamin,

these vitamins, it doesn't necessarily improve your metabolism or your nervous system or brain, particularly because we only need small amounts and we generally tend to have those small amounts unless you're deficient. So if you're deficient, then you tend to have some side effects, some noticeable effects. But regardless of that, we need to get, we generally get these from our diet. And what they do, broadly speaking, is that they do help support energy metabolism.

The B vitamins act as what we call coenzymes. So they help speed up reactions to the degree that actually makes these metabolic processes fast enough for survival. So you could argue that without them, things might still happen, not fast enough for us to survive.

But we do need them. We must have them, otherwise we don't survive. So we do need our B vitamins. Now, I'm not going to go through every single one of them because it's going to take too long. But what I can do is if we're talking about metabolism, B2 and B3, this is riboflavin and niacin. They produce something called NAD plus and FADH. Now, what these two molecules do is they're important coenzymes. They go – so let's just say you eat a delicious cheeseburger, hamburger. Yeah.

And you break it down and you absorb the glucose from it into your hepatocytes, your liver cells. Now, we need to take that glucose molecule, C6H12O6, that's its chemical structure, we need to rearrange it and we need to pluck off the electrons and protons to give to the mitochondria so that it can, through the electron transport chain, make a butt-ton of ATP. Now, the molecules, the coenzymes that pluck off the electrons and protons are,

are NAD plus and FADH. So these B vitamins, B2, B3, riboflavin, niacin, very important to pull electrons and protons, hand them to the electron transport chain, boom, huge amount of ATP. Very important. B5, pantothenic acid, really important because it produces coenzyme A. And coenzyme A is needed to make acetyl-CoA.

And you need acetyl-CoA for the Krebs cycle. And you need the Krebs cycle often for the electron transport chain. You also need the Krebs cycle to make fatty acids.

If you want to store fatty acids. You also need the Krebs cycle because you want to make acetylcholine because acetyl-CoA is a precursor for acetylcholine. So pantothenic acid, B5, is important to make acetylcholine. So is B1. This is thiamine. That's needed to synthesize acetylcholine because it helps turn pyruvate into acetylcholine with the help of B5. And that was obviously the first vitamin discovered.

B1. B1. Hence why it's called B1. Is it? Yeah. Okay. I didn't know why that was. Because it was number one because it was the first one discovered. Makes sense. And I think that was through beriberi, which is a weakness. Beriberi just means weakness in Indonesian language. Right. And I think it was discovered that... Tharmen deficiencies. And that was through they removed certain parts of the rice. So I think they call it polished rice. And they found that people who only had...

polished rice. They developed this vitamin deficiency. Because they weren't making acetylcholine? Must have been. So they just became very weak, irritable, stomach pains, numbness, limbs started to become not working overly well and they got heart failure. Yeah. So it was discovered by...

I guess a Dutch medical doctor who fed polished – because they thought it was an infection. They fed the polished rice to chickens to see if the chickens developed the infection, but instead they got the same thing, but then they found it was a B1 deficiency. There you go. So that's B1, B2, B3, B5. I'm not going to go through all the others, but importantly, they are all – every single one of these B vitamins are part of –

So if you look at glycolysis and the Krebs cycle, if you look at things like the Pentos pathway, other pathways, you'll see that they all fit in in one way or another. And in actual fact, if you want to know exactly where they fit in, I've done a YouTube video. So you can go onto YouTube, type in B vitamins Dr. Mike, and you'll see the best, most detailed video on metabolism and how the B vitamins fit into metabolism. On the whole channel? On the whole YouTube channel?

On the whole internet. In the history of the world. And that, Matthew, are the Bee Vardemans. Merry Christmas. Happy Snow. To make switching to the new Boost Mobile risk-free, we're offering a 30-day money-back guarantee. So why wouldn't you switch from Verizon or T-Mobile? Because you have nothing to lose. Boost Mobile is offering a 30-day money-back guarantee. No, I asked why wouldn't you switch from Verizon or T-Mobile. Oh. Wouldn't. Uh,

Because you love wasting money as a way to punish yourself because your mother never showed you enough love as a child? Whoa, easy there. Yeah.

Hi, I'm Raj Punjabi from HuffPost. And I'm Noah Michelson, also from HuffPost. And we're the hosts of Am I Doing It Wrong? A new podcast that explores the all too human anxieties we have about trying to get our lives right. Each week on the podcast, Raj and I pick a new topic that we want to understand better and bring a guest expert on to talk us through how to get it right.

And we're talking like legit, credible experts, doctors, PhDs, all around superheroes. From HuffPost and Acast Studios, check out Am I Doing It Wrong? wherever you get your podcasts.

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