Dr. Steven Gundry on How Your Microbiome Shapes Your Identity | EP 599
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Find your degree at snhu.edu slash passion. That's snhu.edu slash passion. Coming up next on Passion Struck. We are truly a symbiotic organism and bacteria have been around for 3 billion years.

the most successful life form ever. We've only been around in our current form for about 100,000 years. A lot of us now think that this bacterial part of us, the passengers are driving the bus and they're driving the bus for a really good reason because they've had a lot of experience with living

And again, I make the argument that they are sentient beings. They see, not with eyes like we see, but they can read the barcodes on neighboring bacteria. We've known this for many years. It's called quorum sensing. They know who's in the house. And you go, well, what the heck? How could that be? Well, they carry messages.

Welcome to Passion Struck. Hi, I'm your host, John R. Miles, and on the show, we decipher the secrets, tips, and guidance of the world's most inspiring people and turn their wisdom into practical advice for you and those around you. Our mission is to help you unlock the

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Welcome to episode 599 of Passion Struck. Whether you're a longtime listener or joining us for the first time, I am so grateful you're here. You've turned into a movement dedicated to unlocking your potential, living with intention, and making what truly matters matter most. Before we dive in, let's take a moment to reflect on the incredible conversation I had earlier in the week. On Tuesday, I was joined by Laura and Isabel Hoff, daughters of Wim Hoff,

and authors of Secrets of the Ice Women. We explored how cold exposure, mindset, and breath work can transform hormone balance, emotional resilience, and personal power. And in my upcoming solo episode, number 600, I'll be making a very special announcement that marks a major next chapter for this community. You don't want to miss it. Now let me ask you this. What if your thoughts, cravings,

things. Even your emotions weren't entirely your own. What if trillions of microbes inside you were pulling the strings, shaping your mood

metabolism, and mental health in ways you never imagined. And what if fixing your gut was the key to unlocking peak cognitive performance, resilience, and longevity? That's exactly what we're exploring today with Dr. Stephen Gundry, renowned medical researcher, cardiothoracic surgeon, and bestselling author. In his latest book, The Gut-Brain Paradox, he challenges everything we thought we knew about mental health,

cravings, weight loss, and even free will. In today's conversation, we unpack the groundbreaking science behind how your gut microbes control your brain, mood, and metabolism, why the war on germs might be making us sicker, and what modern medicine needs to rethink, how conditions like anxiety, depression, and even Alzheimer's may actually start in the gut, and a step-by-step roadmap to healing your gut-brain axis and reclaiming your clarity and health.

This episode is a game changer for anyone dealing with brain fog, anxiety, chronic fatigue, or constant cravings. It's also a blueprint for how to regain control of your biology and your mind. And if you want to go even deeper, check out our curated episode starter packs at passionstruck.com slash starter packs or Spotify.

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Now, let's get into this fascinating conversation with the one and only Dr. Stephen Gundry. Thank you for choosing PassionStruck and choosing me to be your host and guide on your journey to creating an intentional life. Now, let that journey begin. Hey, PassionStruck fam. The perfect vacation includes a lot of adventure and even more R&R. And let me tell you, Texas has it all. Whether you're wanting to experience the natural beauty of an iconic state park,

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I am so honored and ecstatic today to have the one and only Dr. Stephen Gundry with me on PassionStruck. Welcome, Dr. Gundry. Hey, thanks for having me, John. It's great to see you again. And I think I want to start there. The last time we spoke, I was in a position I never thought I was going to be in. I was the editor-in-chief of this publication called Bold Business, and I had developed something called the Bold Leader Spotlight, where I

We looked at eight to 10 characteristics of what we thought described someone who was a bold leader. And so I interviewed you as a member of that club. So it's been nearly six years since we last spoke. And since then, your work has continued to push boundaries of what we know about nutrition, disease prevention, and now the link between gut and mental well-being.

What inspired you to shift your focus to the gut-brain connection for this book? With each kind of passing book, since The Plant Paradox came out in 2017, interestingly, the Human Microbiome Project actually finished in 2017. And with every almost passing month, thanks to that project, we now know more

who lives in our microbiome. And for those who don't know yet the microbiome, the microbiome that just lives in our gut probably has 100 trillion bacteria alone, not to mention fungi and molds and viruses and worms. And we're now able to identify who all these creatures are.

and the roles they play in our health. And because we can now identify who they are, we can start to see that the types of bacteria, the balance of good and bad bacteria, really has a huge effect on personality, on

depression, anxiety, addictions, mood. And you can actually do animal experiments and human experiments showing that manipulating these groups of bacteria with food, for instance, or supplements, for instance, can have a huge impact on us. And so this book is a deep dive into

the gut brain paradox that our brain is basically a good receiver for signals from the cloud of our microbiome. Just put it another way, you and I are on computers and I got to you by clicking on a link that took us up to the cloud and here we are.

My computer really doesn't have a lot of computing power. We've put that up into the cloud. A lot of us believe that our genome, human genes, is not very big. But the microbiome genome is enormous. And this genome actually divides constantly and constantly changes. So many of us think that we've uploaded our computing power or downloaded our computing power into our gut.

And the gut then makes the decisions and then it uploads it. I'm holding up my phone near my head. It uploads that information to my brain, which is merely a receiver for that information. And it's an interesting way to think about it. But Hippocrates said 2,500 years ago that all disease begins in the gut. So I'm just trying to catch up with what he knew 2,500 years ago. I'm a slow learner.

Well, you open the book with incredible patient stories, people with Parkinson's, mental illness, even addiction, who all improved dramatically by fixing their gut. How does a single protocol explain such a wide range of transformations? Really, the single protocol works. And again, I see patients six days a week, even on the weekends.

the single protocol works because if people are watching on video i have a big sign behind me a painting the road to health is paved with good intestines and this is what hippocrates taught 2500 years ago and all of these various people that are described in the book all had one thing in common

And that is they had a dysbiotic microbiome. That means they had an imbalance of good guys and bad guys. And they all had leaky gut, intestinal permeability. Now, if you'd asked me 25 years ago when I started this part of my career about leaky gut, I probably would have told you it's pseudoscience. But thanks to work by...

Professor now at Harvard, Alessio Fasano, who identified how leaky gut occurs, how lectins and gluten are a big piece of causing leaky gut, and how we can measure leaky gut with blood tests or stool tests. That's opened up an entire window of opportunity to show, in fact, that somebody with Parkinson's

can be treated by restoring their microbiome into balance and stopping their leaky gut, just as an example. And that same protocol of restoring a balance of microbiome and stopping leaky gut can treat addictive behavior and so on down the line. But about 80% of my practice now is autoimmune patients.

who have been everywhere, tried everything and end up in my office. And 100% of these people have leaky gut and an intestinal dysbiosis, an imbalance of their microbiome. This works. And like I say, I'm a slow learner. Hippocrates clearly knew this 2,500 years ago. He didn't have the human microbiome project to help him out.

But he knew this intuitively, and I spent the last 25 years trying to figure out how he knew it. I want to start with this important yet often overlooked scientific feud that you discuss in Chapter 1. You really go into germ theory, which is Louis Pasteur's theory versus Antoine Mann's terrain theory. And it's interesting because, as we all know, for years and years, Pasteur's approach to

dominated modern medicine leading to this era, probably that led to when you were going to medical school, the focus on antibiotics, germ killing solutions, et cetera. But you actually argue that the terrain theory was actually right all along. And if we were to rewrite the medical textbooks today, what fundamental shift do you think needs to happen?

I'll give you a striking example. One of my friends through the years is Dr. Mark Hyman. And Mark and I were talking just a little bit ago. He has a daughter who's a third year medical student at a very prestigious university.

And in her third year, and there are four years of medical school, she has not had a course on the microbiome, which just flabbergasts him and me. And yet that if we could all give.

credence to what we now know about the influence of the microbiome. What Béchamp knew well over almost 200 years ago now, that it's this, the microbiome in our intestines and in our mouth and in our skin

which I call the holobiome, is akin to a tropical rainforest. And there's all these interconnected species that are dependent on each other, bad guys, good guys, but they're all in perfect balance. And Machamp was arguing with Pasteur that germs per se were not bad or good. It was when the balance was

of this tropical rainforest or as he called the terrain became in balance that's when a disease or an infection started and unfortunately Pasteur was a much better public speaker as Stewart was discovered that was bacterial contamination of

wine, grapes being fermented in wine by yeast that caused it to go bad. And obviously, he was a big hit with the King of France finding that out. So he was elevated to a great place of honor. And Béchamp was relegated to the obscurity. But as I write about in the book, and I've read every book about both of them, many of the books cite that on his deathbed,

Pasteur called Béchamp and his colleague Bernard to his bedside and he said, you're right. It was the terrain. I hope the story is true because it sure makes sense. But so again, we don't even teach this in medical schools. I'll give you a great story. I was just reading today. So one of my feeds.

about the new exciting research into the treatment of IBS and ulcerative colitis and what I do every day. And the article was going on and on about this poor young lady who was on steroids and other immune suppressing drugs. And her mother was not happy with the fact that she was on this

And the exciting part of the article was, well, there's now we know so much more about immune suppressing drugs that we now can really pinpoint what we should be doing. And buried down at the bottom of the article was the fact that this young lady figured out that was actually the food that she was eating that was her problem.

and that she now tailors the food that she eats and she no longer has this problem. She's off of all drugs. And she's actually created a business where she provides food services for people with IBS and ulcerative colitis. Imagine that. But the entire article was basically, oh, the miracles of all these modern drugs.

I'm a transplant immunologist by training as a heart surgeon and a heart transplant surgeon. And when I have a patient walk in on these immune suppression drugs,

I go, I didn't do a heart transplant on you. You don't have a kidney transplant. You don't have a liver transplant. So what the heck are you doing on a transplant drug? And they go, yeah, you're right. What am I doing on that? The immune system is being told to look the other way. And that's not what we want to do. We want to find out what the immune system is revved up about. That's what we do.

Yeah, it reminds me of one of the interviews I did last year on the podcast with Dr. Terry Walls, who you probably know. Good friend. And I think hers is a story that kind of parallels that. She was suffering from multiple sclerosis.

if I have it correct, and had gotten to the point where she was actually in a wheelchair when she started to change her whole diet. And over time, she found herself riding a bike again and exercising and living a normal life. And one of the things that I really love about her work is she does a lot of

patient care in the VA system. And so veterans who have exhausted all Western medicines, she invites into her clinic, but says, if you're going to commit to it, you have to commit to exactly what I tell you to do. And her results have been pretty fascinating.

I have a very similar philosophy here. I can show you the path, but it's you who must walk it. And we can see people who stray. We do leaky gut tests usually every three months in our patients.

And we can see slip ups or we can see where they're really doing spectacular. And the fun stuff is it's measurable stuff. We can watch it. Just actually before I got on this podcast, I have a young man who flew in from Midwest. He's 50 years old, had really horrible leaky gut, had liver inflammation from his leaky gut. He had vascular inflammation from his leaky gut.

He's now six months into this, and his repeat leaky gut test is 75% better than six months ago. His antibodies to the various forms of wheat are 75% gone compared to six months ago. His liver inflammation is gone. His vascular inflammation is gone.

And he's just sitting there going, oh my gosh, look, this works. This isn't a placebo effect. He said, oh yeah, I can see it. And it's, yeah, I didn't make this up. And the excitement that people see without immunosuppressant drugs is, why get up every morning and watch this? If you're a listener or a viewer, what are some signs that you might have a leaky gut?

I made the bold statement back when I wrote The Plant Paradox that if you have any disease process, whether it's a migraine headache, whether it's high blood pressure, whether it's diabetes, whether it's coronary artery disease, whether it's arthritis, whether it's a skin rash, whether it's any autoimmune disease,

then you have leaky gut. I'm sorry, get over it. And Hippocrates knew this. Hippocrates, I've tried to read as much as I can about his teachings. Hippocrates believed that all of us have a green life force energy, which is very California speak, that wants us all to have perfect health and that

there were external factors that would suppress the expression of this green life force energy. And Hippocrates thought that a physician's job was to be a detective and to find out what these external factors were and teach the patient to remove them. And then the patient's green life force energy would solve the problem, would heal the patient. And

He was right. And all I do is be a detective and teach the patient to remove these external factors. Now, since the Human Microbiome Project, the green life force energy is actually our microbiome. So maybe we should call it the brown life force energy to be more descriptive. But our microbiome, this is their home and they

would like their home to be around for a considerable period of time. It looks like.

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You mentioned Dr. Mark Hyman a few minutes ago, and he's also my friend. I've had him on the show a couple of times. And a couple episodes ago that I did with him, we were talking about the latest book he had published, and we were going through biological age and how to extend it compared to

our chronicle age. And so we spent a lot of time also talking about the microbiome. And one of the things you both talk about, and it's one of the most mind blowing takeaways, I think from your book is that about half of the cells in our bodies are not actually human, they're microbial. And you take this even further by suggesting that we need to rethink what it even means to be human. Can you expand on that?

My previous book, Gut Check, I introduced people to a little one-cell organism called toxoplasmosis, which is a single-cell parasite that has, like many parasites, has two life cycles. And many parasites have to spend some time in an intermediate host to get to their final place they really want to get to.

toxoplasmosis wants to get into a cat and that's where it wants to go and its intermediate host is strangely selected to be a mouse or a rat now that's a really you would think a dumb idea because mice and rats are deathly afraid of cats if they smell cat urine they run the other direction but

toxoplasmosis gets into a rat or a mouse through contaminated water that a cat has pooped in and it basically goes to the brain and literally rewires the brain primarily using dopamine receptors and it makes the smell of cat urine sexually stimulating to the rat

And it also makes the sight of a cat incredibly exciting. And the rat literally runs to danger and gets eaten. Now, what's so interesting about that is we know that great apes, particularly chimps, can be infected with toxoplasmosis. And why? Because believe it or not, tigers, big cats, chimps are one of the favorite foods.

And these animals become emboldened around tigers. Great studies out of Yellowstone Park showing that most wolf pack leaders are infected with toxoplasmosis because believe it or not, the predator of a wolf is a cougar, a mountain lion. And they become more bold, take more risks. And that's actually how they become leaders.

What's really scary is that humans can be infected with toxoplasmosis and people who are infected with toxoplasmosis. For instance, the vast majority of motorcycle riders in fatal accidents are infected with toxoplasmosis. And at one point, the U.S. military was very interested in infecting troops with toxoplasmosis so that they would run towards danger.

So the reason I brought that up in that book and the reason I talk about more of this in this book is the power of a single cell organism to completely rework our thought process for that organism's benefit. And in that case, it's a parasite. But the parallel is

the organisms if they're in balance within us want us to try and get the food that they need to take care of their apartment building and if everything is in balance like Bishop believed then that makes a really good place to live and keeps us alive in fact

Mark and I obviously, and I wrote The Longevity Paradox. One of the things that, to paraphrase Hippocrates, is that death begins in the gut. And you look at all these super old people, and he and I study them around the world. None of these people have leaky gut. They have this incredibly rich, diverse microbiome.

And they have a microbiome that literally fends off all these environmental toxins. They eat plastics, for instance. And people go, what? They eat plastics? Well, we have bacteria that eat oil spills and plastics are merely petrochemicals. They're just looking for carbon atoms. So again, the road to health is paved with good intestines and that's all.

There was, and I know you talk a lot about lectins, and that's one of the things you're known for the most. But if someone is suffering from leaky gut, what are one or two of the foods that they're probably eating that they should eliminate completely out of their diet? I'll give you a great story. You mentioned this wonderful woman who had Parkinson's that I start the book with.

And I won't go into her whole story, but she had very leaky gut. She was very sensitive to gluten, a component, a lectin in wheat, rye, barley. There's also a molecule in oats and corn that cross reacts with gluten, just as an example. And she had antibodies to all these. And we changed her diet. We took these things away.

And within a year, her leaky gut was gone. And within a year, her Parkinson's symptoms really completely abated. She was back running again. She didn't have a tremor anymore. And I saw her and her husband about a month and a half ago for her two-year follow-up. And she still looked really good. And she said, I don't know. I think I'm slipping. I can feel myself slipping. I don't know what it is.

but are just not as good the last few months. And I said, well, let's look at your blood work. Let's look at your leaky gut. And sure enough, her leaky gut was still pretty good, but it was not as good as six months ago. Then she had some antibodies to gluten that she didn't have.

And I said, I know you so well by now, but are you eating out more? Are you going to restaurants? Are you cheating? She said, oh no, I wouldn't cheat. Why would I? And I said, well, something's different. I said, you're getting exposed to gluten. And her husband perks up and he said, would sharing a cutting board with somebody who's cutting bread, regular bread on a cutting board do this? And I said,

What do you mean? He says, well, our son who's 30 moved in with us about four months ago and he doesn't follow our diet. And every day he cuts bread on the cutting board. And then we have our bread that is safe and we use the same cutting board. And I said, son of a gun. And when did you start noticing you were changing? And she said, it's when our son moved in with us.

And so we could see it on the blood test. She knew it. And that was the contamination in her. Now people go, oh, come on, a few breadcrumbs? If you told me this, again, 30 years ago, I would have laughed you out of the room. But there it was. We could see it. She felt it. And again, Hippocrates was right. Just be a detective.

And there it was. That was the thing that was now stopping her green life force energy from expressing itself. And it sounds so hokey. I mean, it does, because when you think about it, like you said, it's probably just dust on the board. It's not, it's just residual. Just a few molecules of gluten in some of my, what I call my canaries, is enough to do this. Again, I would have

told you these people are just crazy. They're not. And we can actually measure it. And it's like, son of a gun. You're right. Look, your gut is leaky again. Look, you've got antibodies to gluten. Where'd you get those from? There it was, the sun. I appreciate you sharing that. And I want to shift the discussion to, of all topics, free will. Because you write in the book that microbes don't just live inside of us.

they actually control us. They dictate what we crave, how we think, and even how we feel. And this is a radical idea. Can you explain just how much power these microbes have over our behavior? To me, again, if I look back, this seems like an incredibly radical idea. But Deepak Chopra has been talking about the intelligence

of single cells, the sentient beings. Some people now want to talk about the intelligence of mitochondria, which are the energy producing organelles in all of our cells, which are actually engulfed bacteria. And I've come around to the way of thinking that we are truly a symbiotic organism.

And that bacteria have been around for 3 billion years, the most successful life form ever. And we've only been around in our current form for about 100,000 years. And that a lot of us now think that this bacterial part of us

is driving. The passengers are driving the bus, and they're driving the bus for a really good reason, because they've had a lot of experience with living. And again, I make the argument that they are sentient beings. They see, not with eyes like we see, but they can read

the barcodes on neighboring bacteria. We've known this for many years. It's called quorum sensing. They know who's in the house. I'll give you an example. There's a keystone species in our gut that's called Ackermansia mucinophilia. And there's a company that makes a probiotic, Ackermansia, that is a living bacteria. And I'm a big fan of them. They're called Pendulum.

But there are also companies that make dead acromantia. In other words, they're not living. What's really interesting is swallowing live acromantia has measurable effects, but swallowing dead acromantia has measurable effects, but beneficial effects. And you go, well, what the heck? How could that be? Well, they carry messages. I had a chapter in Gut Check, my current book, that dead men tell no tales, but dead bacteria do.

And so we're beginning, we're getting come to grips with what seems basically just incredibly impossible. But final, I have a Sanskrit Buddhist scholar as one of my patients. And we were discussing this one day about Hippocrates and gut health and all disease comes from the gut. And he says, I'll be back. And he comes back.

He says, I've read all the Buddha's sayings in Sanskrit. He said, do you know what Buddha said? Buddha was a contemporary of Hippocrates. He said, enlightenment comes from the intestines. And I'm going, son of a gun. How did these great ancient wisdom? I don't know. Were the bacteria telling them about this? But we have to give these guys a little more respect.

So I want to ask maybe a follow-up question to this, and I'll phrase it like this. Many people, including myself, struggle with food cravings, and we think it's a willpower issue, but you suggest that it's actually their gut bacteria calling the shots. And I think this kind of goes into what you were just talking about. Can you break down how that works?

Yeah, I was first enlightened about this a few books ago. There was a fascinating Chinese study where they took volunteers and they put them on a 14-day water fast. All they got was water, which is a long time. And half the group were given 100 calories of prebiotic fibers.

Now, we can't absorb this prebiotic fiber. We can't digest it. So we can't get 100 calories from it. But the gut bacteria, the important gut bacteria, this is what they love to eat. And what they found was that the people who were on a water fast were really hungry. Now, eventually that hunger went away, but it took a long time. But the people who got the 100 calories of prebiotic fiber had no hunger for 14 days.

Now, it's called the gut-centric theory of hunger. And it basically says that these guys, if their needs are being met, they send text messages. In fact, GLP-1, which is the in thing, are made by gut bacteria. And it tells the brain, hey, we've got everything we need. You don't have to go looking for anything else. We're fine.

Now, why are all of us continually hungry? Why do we want other foods? Well, because as I talk about our great, great grandparents ate whole food and they ate that whole food whole. And there was lots left over after we digested it into sugars and amino acids and fats.

that kind of filtered down to our colon where most of these guys live with all this stuff that they like to eat all this prebiotic fiber and so everybody was satisfied in fact go ahead look at every picture from the 40s 50s even 60s of human beings and everybody was skinny because we were actually eating a lot of whole foods in fact we're eating more calories then

Now, almost everything is processed or ultra processed, and we've stripped away all of this prebiotic fiber. And what happens is that these guys can hear us chewing. They hear us swallowing. They can hear the stuff coming down. They say, oh boy, it's coming. And nothing arrives. And I go, what the heck? I heard you eating. We've been gypped. Go find some more.

and keep eating until we get something. And you see the side effect of that. I thought that was one of the most fascinating and quite frankly, disturbing things that I read in the book is that our bad gut bugs actually hijack our hunger signals, making us crave the very foods like you were just talking about that allow them to multiply.

These bad guys can use simple sugars and they can actually use fats that the good guys can't. And the bad guys have actually gravitated higher in our intestines to grab this stuff before anybody else can. And people go, wait a minute, they're moving around in your intestines to grab this stuff. I'll give you an example. One of my offices is in Santa Barbara and

the Santa Barbara Channel, we have whale watching. And for many years, all we had was the California gray whale. And they're not exactly cute and they're a little boring. But over the last few years, we now have huge pods of blue whales. We now have humpback whales, humpback whales from Hawaii. And we now have pods of killer whales.

And it's what the heck are those doing in Santa Barbara and in the Channel Islands? Well, because with climate change, their food sources have migrated. And all they do is follow the food sources. And what I want people to realize is that these bacteria are sentient beings. They are following food sources, number one.

And number two, they are directing us, the food consumer, to get the food sources that they want. And I'm sorry, get over it. These guys have had three billion years to work this out. If you're someone who has these bad microbes controlling you and you want to reset your system,

to let the good microbiome come into play more. What are some of the best ways to do that, in your opinion? And it's all in the book. First of all, you got to starve these bad guys of what they need. And those are processed foods, simple sugars and fats. Number two, you got to give the good guys what they need to eat.

And that includes prebiotic fibers. Inulin is a great prebiotic fiber in asparagus and artichoke hearts and in the chicory family of vegetables like radicchio or Belgian endive. You can take supplements like psyllium husk, like chicory supplements, which work great.

but you also have to get a lot of polyphenols in your diet now polyphenols we've learned really only the last few years are some of the favorite foods of the good gut bacteria and polyphenols are these bright dark colored fruits and vegetables that you can get and many of the supplements that

I manufacture at GundryMD are polyphenol-based supplements. That's actually what made GundryMD famous. So polyphenols. But the third piece of the puzzle is you've got to get fermented foods into you or the products of fermentation. And one of the easiest things for everybody to do is add more vinegars into their diet.

vinegar is a product of fermentation it's a post biotic and we now know that it's the products of fermentation that actually give the good guys the gut buddies the one up on everybody else and one of the easiest things for people to do get yourself some sparkling water buy some balsamic vinegar

Put a tablespoon of balsamic vinegar in a glass of sparkling water and have a fake Coke, as I called it years ago. And it's a great way, or put apple cider vinegar in it. It's an easy way to give the gut buddies what they need to eat. Finally, we know that vitamin D, the higher your vitamin D level, the more diverse your microbiome.

And again, the more diverse, the more this terrain is balanced and diverse, the better your health. Well, thank you for sharing that. And I wanted to now switch to another topic that I think is becoming more prevalent in society, and that's cognitive decline. And I know whether it's Alzheimer's or dementia, both are significantly on the rise. And I've

Had discussions with neurologists talking about this from a neuroscience standpoint about how different plaque and amyloids aren't getting cleaned out from the system. But I'm also wondering, could this also be stemming from gut dysbiosis that is also contributing to cognitive decline? Yeah, absolutely. As my friend Dale Bredesen will remind anyone who will listen,

If the tau protein and amyloid plaque theory of Alzheimer's or cognitive decline was right, then $20 billion later, we ought to have an effective drug targeting those. And as anyone knows, this has been a dismal failure. Every one of these drugs has been a failure despite cleaning out amyloid plaque and tau proteins.

So I like to use the example after 9-11, all of us remember that all of a sudden barriers, concrete barriers were erected in front of government buildings, in front of airport entrances, wherever we thought or suspected a terrorist could drive a car or a truck or something through. And we now know that with leaky gut,

bacterial particles or living bacteria can get through the wall of the gut and they're recognized as attacking. 80% of all of our immune system, our white blood cells are down in our gut. And they're, if a way of saying they're an early warning system and they send text messages up to the white blood cells in our brain, which are called microglia.

And these guys are really the bodyguards of the neurons. And they get the message, oh my gosh, the army is advancing on the brain. Do everything you can do to protect these neurons from harm.

And so I like my patients to visualize that these amyloid plaques and these tau proteins are merely concrete barriers that have been erected in the brain to protect the neurons from the terrorists who are on the way. And the more people understand that this is merely a response

to what's going on in the gut. That's how, you know, this young lady with Parkinson's reversed her Parkinson's because there was no longer a threat and we were no longer at threat level five or whatever it was. And we could stand down and we can also watch microglia.

actually nibbling like Pac-Man the dendrites of the neurons communicating to other neurons, trying to bring guys back into the fort, circle the wagons because the Indians are attacking. And so we can watch this. And I was lecturing at a neuroscience conference at Harvard a few years ago about this. And one of the professors stood up and he says, so what's wrong with moderation and everything?

And because I was saying, look, here's the cause of leaky gut. We got to get these guys stop this. And he's going, what's wrong with moderation? And I said, that's fine. If you want moderate memory loss, moderate heart disease, moderate arthritis, go right ahead. I don't want that. He had no response. I can see why he had no response, given where you were speaking at.

One of the things I wanted to touch on, because as I was reading chapter seven, thought it was something that was important to cover is the topic of SSRIs. And you make the compelling case that antidepressants like these don't just increase serotonin, they also alter the microbiome. And I heard you talking to Ed Milet about this on his podcast.

about how you notice this because when you take an SSRI, if it's really doing what it's supposed to do, just increasing serotonin, then you would expect it to work within 12 to 24 hours, but that's not

how it works. Correct. If this is true, should we be looking at healing the gut as a first treatment for depression instead of prescribing these types of drugs? I'm not against pharmaceuticals. They have a place, but I view them... If I break my leg, I'm going to let somebody put a cast on it and my leg will heal, but I certainly am not going to need a cast the rest of my life. Once it's healed,

I don't need the cast. And I view a lot of these pharmaceuticals, whether, for instance, a statin drug or an SSRI as potentially beneficial until we can fix the underlying problem. And the underlying problem I submit is gut dysbiosis and a leaky gut. And what's interesting with these SSRIs is that indeed,

They do change the gut microbiome into a much more rich, biodiverse gut microbiome than when you started with. And people with depression and anxiety have a really dysbiotic gut microbiome with some bad actors that have overgrown. And a lot of this is thanks to the active ingredient around glyphosate, which actually targets glyphosate.

the tryptophan, serotonin pathway bacteria and kills them and allows other bugs which are resistant to round up to flourish. And these SSRIs take a month, even more to kick in because the gut microbiome doesn't change instantaneously. It takes quite a bit of time, as I've learned through the years, to change the gut microbiome.

And so it's the same way. I'll give you another example. Metformin, the famous diabetic drug. We thought there was all these magical, mystical ways that metformin improved mitochondrial function, et cetera, et cetera.

But now comes to find out that metformin actually works most of its magic by changing the microbiome, by actually promoting the growth of this keystone species, Acromancea. And it takes a while for it to kick in. And what was interesting to me in patients who I had or put on metformin to treat their diabetes or their insulin resistance,

About 30% of them would get really interesting gut issues. Diarrhea is a known side effect of metformin. And about 30% of people get diarrhea so bad with metformin that they can't take it. And it's because it's changing the gut microbiome, not because of any side effect of these drugs.

When you start looking at all of these drugs now, even for hypertension, you begin to see these changes in the gut microbiome that are happening from these drugs. So rather than saying, oh, the drug is having this effect on this person's blood vessels. No, it's having this effect on changing the microbiome. And why don't we just go and change the microbiome and then we won't need these drugs. And this is what I learned

early on when I was still a professor at Loma Linda, having people follow this program. And these people who I operated on were on two or three antihypertensive drugs. They were having hip replacements and they were, many of them were diabetics. And as we went along through the months, they're throwing their blood pressure meds away. They're

throwing their diabetes drugs away or they're lowering their insulin. And I'm going, this is amazing. Wow. Look at this. Just by having them eat certain foods and not eating other foods and going to the health food store and buying a few supplements, look at this. And that's what made me do a leap of faith and quit as chairman and professor of heart surgery and

set up a clinic where I just teach people eat. What an idiot. But Hippocrates was right. And so we see all of these effects just by getting these guys the food they need and stop swallowing razor blades, as I call lectins. Is it hard work? But is it worth it? Most people think so. So my final question for you, Dr. Gundry, is gut research is still in its early days. Where do you think the most

important area of the field is heading in the next five to 10 years? Well, we talk about personalized medicine and we talk about, well, let's look at your genes and see what your genes determine and snips. We have to realize that our genome isn't very interesting. There are more genes in corn than in humans. There's more genes in a sand flea than in humans.

But the microbiome genetic material is incredibly vast. And the cool thing about bacteria is their genome can be exchanged between bacteria and the viral genome is capable of changing the bacterial genome instantaneously. And these guys are constantly dividing. And so they're just swarming with genetic information.

What we now know, because of the Microbiome Project, we can do personalized medicine by knowing which bacteria does what, which messages bacteria send to control our mitochondrial function, our cellular function. I just recently came back from the annual meeting of, get ready for this, the Society of Extracellular Vesicles.

And it's like, so we now know that bacteria and plants can send packets of genetic information to through our body to hook up with a cell, a target like a neuron in the brain to tell that neuron to do something completely different that will be a benefit or a detriment to the body as a whole.

And we can now, we can see these text messages. We can look and find out what that text message is. And the idea, again, that these little single cell organisms are so sophisticated that they can send out pieces of genetic material that will bind with our genes, epigenetic activity,

It's just the holy cow. Talk about personalized medicine. We'll know which bacteria are missing. Well, we already know which bacteria are missing in certain people. And the exciting thing is we're beginning to find out what it takes to give each of these bacteria what they need to grow and prosper.

It's not enough to just swallow these bacteria. I can assure you, you got to know what they want to eat. You got to know what the bacteria next to them is making that they also need to eat. And so it's a complex recipe. And since I was trained as a chef by my mother, you just have to figure out all the ingredients that make the perfect cake. And that's what's going to be exciting.

Dr. Gundry, congratulations on this fantastic book, The Gut-Brain Paradox. It's always such an interesting discussion every time I have it with you. And I know you're easily discoverable, but can you tell the listeners the best place to find out more about you, your work, and your products? So they can go to GundryMD.com, my supplement food company, DrGundry.com, all about me.

Got two YouTube channels, Instagram. Hopefully I appear when people are surfing the web, waving at them with some wonderful something to talk about. And you can get the book wherever books are sold. I've had multiple New York Times bestsellers, so they're in most bookstores. Yep. You've sold millions of them and have had tens of millions of views on YouTube.

Well, sir, thank you so much for coming on today. It was such an honor. Great to see you again. And thanks for having me on your new podcast. And that's a wrap. What an incredible conversation with Dr. Stephen Gundry. His insights into the gut-brain connection, the hidden influence of our microbiome, and the groundbreaking science behind the gut-brain paradox have truly reshaped how we think about mental clarity, cravings, energy, and long-term health. This isn't just about digestion.

It's about how we feel, how we think, and how we live. So as we close out today's episode, I invite you to reflect on a few key takeaways. What daily choices are you making that either support or sabotage your gut? Are your cravings and energy crashes actually being driven by your microbiome? And what would it look like to take back control, not just of your diet, but of your mind?

If today's conversation resonated, please take a moment to leave a five-star review. It's one of the best ways to help this movement grow and to bring conversations like this to more people around the world. And if someone in your life could benefit from Dr. Gundry's wisdom, send this episode to them. A single share can spark real transformation.

All the resources we discussed, including Dr. Gundry's latest book, are in the show notes at passionstruck.com. And if you want to see today's conversation, check out the full video on my John R. Miles YouTube channel. And while you're there, hit subscribe and join the community. If you're looking to bring these kinds of insights into your company, your team, your organization, head over to johnrmiles.com speaking to learn how we can work together. On our next episode, number 600, I'll

I'll be sharing a powerful solo message that marks a major milestone for this podcast and this community. We'll celebrate how far we've come, and I'll be unveiling something brand new that I've been working on behind the scenes for months. You won't want to miss it. Then I'll be joined by Yonge Mingor Rinpoche, one of the world's leading voices in mindfulness and meditation. We'll explore how joy and awareness can coexist with emotional pain. We do a deep dive on the Buddhist perspective of mattering,

and how to train your mind to become a tool for healing and deep present moment living. It's a beautiful conversation, profound, practical, and grounded in a lifetime of wisdom. At a certain level, I discovered that I have panic or panic, what I call that

aversion to panic, resist, feeling of resistance to the panic attacks. I'm fighting with my panic actually. And my father said, "Don't fight, welcome the panic." Then I begin to welcome that a bit. It helps a little bit. And I thought, "Oh, now I know the new strategy." So if I say welcome, then panic will not come back. It's become a little bit like dog chasing tail.

But even that fake welcome helps for me. And remember, the fee for the show is simple. If you found value in today's episode, share it, text it, post it, email it to someone who needs to hear it. Because knowledge doesn't change lives. Action does. Until next time, live life passion-struck.