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#19 - Dave Feldman: stress testing the lipid energy model

2018/10/8

The Peter Attia Drive

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#19 - Dave Feldman: stress testing the lipid energy model

The Peter Attia Drive

What is Peter’s synthesis of Dave’s energy model?

How did Dave’s journey transform from software engineering to cholesterol research?

What impacts particle numbers in standard blood and sterol panels?

Who are hyper-responders?

Lipoprotein transport

Understanding the lean mass hyper-responder phenotype

The progression of atherosclerosis, CAC, and CIMT

How is oxidized LDL tested?

What are the implications of all-cause mortality and clinical endpoints?

Does LDL causality affect health?

What were the results of Dave’s low carb cholesterol challenge and drug & genetic study qualifications?

If LDL-P is high but other markers are healthy, what is the risk? Case studies and self-experiment

What were the findings of Peter’s three-day exercise and ketosis experiment?

What are remnant lipoproteins?

What might cause higher LDL particle numbers in lean mass hyper-responders?

A case study of a lean mass hyper-responder by Dave

Exploring mass balance and cholesterol flux

Can a higher degree of cholesterol explain the lean mass hyper-responder phenotype?

What were the results of Peter’s LDL during his keto-fast-keto experiment?

Does substituting saturated fats with monounsaturated fats affect LDL-P and LDL-C?

What were the outcomes of Dave’s carb-swap experiments?

What did Dave’s carotid intima-media thickness tests reveal?

Looking for studies that stratify for high HDL-C and low TG alongside low and high LDL-C

Shownotes Transcript

#19 - Dave Feldman: stress testing the lipid energy model 03:10:16 Share

The Peter Attia Drive

What is Peter’s synthesis of Dave’s energy model?

How did Dave’s journey transform from software engineering to cholesterol research?

What impacts particle numbers in standard blood and sterol panels?

Who are hyper-responders?

Lipoprotein transport

Understanding the lean mass hyper-responder phenotype

The progression of atherosclerosis, CAC, and CIMT

How is oxidized LDL tested?

What are the implications of all-cause mortality and clinical endpoints?

Does LDL causality affect health?

What were the results of Dave’s low carb cholesterol challenge and drug & genetic study qualifications?

If LDL-P is high but other markers are healthy, what is the risk? Case studies and self-experiment

What were the findings of Peter’s three-day exercise and ketosis experiment?

What are remnant lipoproteins?

What might cause higher LDL particle numbers in lean mass hyper-responders?

A case study of a lean mass hyper-responder by Dave

Exploring mass balance and cholesterol flux

Can a higher degree of cholesterol explain the lean mass hyper-responder phenotype?

What were the results of Peter’s LDL during his keto-fast-keto experiment?

Does substituting saturated fats with monounsaturated fats affect LDL-P and LDL-C?

What were the outcomes of Dave’s carb-swap experiments?

What did Dave’s carotid intima-media thickness tests reveal?

Looking for studies that stratify for high HDL-C and low TG alongside low and high LDL-C

Shownotes Transcript

#19 - Dave Feldman: stress testing the lipid energy model