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#216 - Metabolomics, NAD+, and cancer metabolism | Josh Rabinowitz, M.D., Ph.D.

2022/8/1

The Peter Attia Drive

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#216 - Metabolomics, NAD+, and cancer metabolism | Josh Rabinowitz, M.D., Ph.D.

The Peter Attia Drive

Josh’s background and unique path to becoming a research scientist at Princeton?

What sparked Josh’s early interest in metabolism?

Metabolomics 101: defining metabolites and how they are regulated?

Fluxomics: metabolism as a system in action?

The Randle Hypothesis: glucose and fatty acids compete as substrates for oxidation?

The important role of lactate as an alternate fuel?

Fasting lactate levels as a potential early indicator of metabolic dysfunction?

The beauty of the Krebs cycle and the role of NAD in energy production?

How the drug metformin acts on complex I of the electron transport chain?

The difference between NADH and NADPH?

NAD levels with age, and the efficacy of supplementing with intravenous NAD?

The usefulness of restoring NAD levels and efficacy of oral supplementation with NAD precursors NR and NMN?

Exploring the hypothesis that boosting NAD levels is beneficial?

Cancer metabolism and the intersection with immunotherapy?

Making cancer a chronic disease: exploiting the metabolic quirks of cancer, augmenting the immune system, and more?

The challenge of treating pancreatic cancer?

Epithelial cancers that might respond to metabolic approaches to therapy?

Josh’s hopeful outlook on the future of cancer treatment?

Nutritional approaches to cancer attenuation?

What makes Princeton University special?

Shownotes Transcript

#216 - Metabolomics, NAD+, and cancer metabolism | Josh Rabinowitz, M.D., Ph.D. 02:11:37 Share

The Peter Attia Drive

Josh’s background and unique path to becoming a research scientist at Princeton?

What sparked Josh’s early interest in metabolism?

Metabolomics 101: defining metabolites and how they are regulated?

Fluxomics: metabolism as a system in action?

The Randle Hypothesis: glucose and fatty acids compete as substrates for oxidation?

The important role of lactate as an alternate fuel?

Fasting lactate levels as a potential early indicator of metabolic dysfunction?

The beauty of the Krebs cycle and the role of NAD in energy production?

How the drug metformin acts on complex I of the electron transport chain?

The difference between NADH and NADPH?

NAD levels with age, and the efficacy of supplementing with intravenous NAD?

The usefulness of restoring NAD levels and efficacy of oral supplementation with NAD precursors NR and NMN?

Exploring the hypothesis that boosting NAD levels is beneficial?

Cancer metabolism and the intersection with immunotherapy?

Making cancer a chronic disease: exploiting the metabolic quirks of cancer, augmenting the immune system, and more?

The challenge of treating pancreatic cancer?

Epithelial cancers that might respond to metabolic approaches to therapy?

Josh’s hopeful outlook on the future of cancer treatment?

Nutritional approaches to cancer attenuation?

What makes Princeton University special?

Shownotes Transcript

#216 - Metabolomics, NAD+, and cancer metabolism | Josh Rabinowitz, M.D., Ph.D.