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#222 ‒ How nutrition impacts longevity | Matt Kaeberlein, Ph.D

2022/9/12

The Peter Attia Drive

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#222 ‒ How nutrition impacts longevity | Matt Kaeberlein, Ph.D

The Peter Attia Drive

What are the challenges in studying nutrition and aging interventions?

How have Peter and Matt's views on optimal health evolved?

Does calorie restriction improve lifespan in animal models?

What is the utility of epigenetic clocks and the possibility of reprogramming?

How do mutations and changes to the epigenome affect aging?

What are the potential benefits and downsides of epigenetic reprogramming?

What are the first potential applications of anti-aging therapies?

How does calorie restriction impact the immune system, muscle mass, and strength?

What insights can be gained from calorie restriction studies in rhesus macaques?

What is the evolutionary perspective of the human diet?

Can anti-aging diets separate fact from fiction?

What do mouse models of time-restricted feeding reveal about calorie restriction?

Which nutritional interventions consistently impact lifespan in mice?

Does the impact of calorie restriction differ when started later in life?

How does rapamycin extend lifespan in older mice?

Does protein restriction extend lifespan in mouse studies?

How does protein intake impact mTOR and muscle loss?

What are the effects of low-protein vs. high-protein diets on muscle mass and mortality?

How does IGF-1 signaling and growth hormone impact lifespan?

What are the parting thoughts on nutrition's contribution to healthspan and lifespan?

Shownotes Transcript

#222 ‒ How nutrition impacts longevity | Matt Kaeberlein, Ph.D 02:27:23 Share

The Peter Attia Drive

What are the challenges in studying nutrition and aging interventions?

How have Peter and Matt's views on optimal health evolved?

Does calorie restriction improve lifespan in animal models?

What is the utility of epigenetic clocks and the possibility of reprogramming?

How do mutations and changes to the epigenome affect aging?

What are the potential benefits and downsides of epigenetic reprogramming?

What are the first potential applications of anti-aging therapies?

How does calorie restriction impact the immune system, muscle mass, and strength?

What insights can be gained from calorie restriction studies in rhesus macaques?

What is the evolutionary perspective of the human diet?

Can anti-aging diets separate fact from fiction?

What do mouse models of time-restricted feeding reveal about calorie restriction?

Which nutritional interventions consistently impact lifespan in mice?

Does the impact of calorie restriction differ when started later in life?

How does rapamycin extend lifespan in older mice?

Does protein restriction extend lifespan in mouse studies?

How does protein intake impact mTOR and muscle loss?

What are the effects of low-protein vs. high-protein diets on muscle mass and mortality?

How does IGF-1 signaling and growth hormone impact lifespan?

What are the parting thoughts on nutrition's contribution to healthspan and lifespan?

Shownotes Transcript

#222 ‒ How nutrition impacts longevity | Matt Kaeberlein, Ph.D