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#253 ‒ Hormone replacement therapy and the Women’s Health Initiative: re-examining the results, the link to breast cancer, and weighing the risk vs reward of HRT | JoAnn Manson, M.D.
01:20:48
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2023/5/8
The Peter Attia Drive
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What were the original goals of the Women’s Health Initiative and the hormone formulations used?
Can you explain the study design of the Women’s Health Initiative and its primary outcome?
What was JoAnn’s hypothesis about HRT reducing heart disease risk before the WHI?
How does estrogen relate to breast cancer?
Why was the WHI study stopped early, and what were the consequences for HRT usage?
What are the nuanced benefits and risks of HRT according to Peter?
How does HRT affect bone health?
What is the importance of timing in HRT and how to find the right clinician?
Could long-duration HRT impact mortality?
How can we improve HRT practices and what studies are needed?
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