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#27 - David Sinclair, Ph.D.: Slowing aging – sirtuins, NAD, and the epigenetics of aging
01:41:23
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2018/11/5
The Peter Attia Drive
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How and why did David move from Australia to Leonard Guarente’s lab at MIT?
What are sirtuins and their role in aging?
Experiments elucidating the mechanisms of sirtuins
How are sirtuins activated?
NAD and sirtuin activation
Nicotinamide, sirtuin inhibition, and PNC1
Resveratrol
The NIH/ITP studies on resveratrol
Does David take any compounds for longevity?
NAD precursors (NR, NMN) and pterostilbene
Female fertility and NAD precursors
A unifying theory of aging
Waddington’s epigenetic landscape
If David had unlimited resources, what experiment would he do?
Testing combinations to extend lifespan
What made David aware of his mortality at such a young age?
What is David’s book going to cover?
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