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#272 ‒ Rapamycin: potential longevity benefits, surge in popularity, unanswered questions, and more | David Sabatini, M.D., Ph.D. and Matt Kaeberlein, Ph.D.

2023/9/25

The Peter Attia Drive

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#272 ‒ Rapamycin: potential longevity benefits, surge in popularity, unanswered questions, and more | David Sabatini, M.D., Ph.D. and Matt Kaeberlein, Ph.D.

The Peter Attia Drive

What are David and Matt's insights on mTOR and rapamycin?

How was rapamycin discovered and first used in humans?

Can rapamycin potentially prolong lifespan?

What were the findings of the rapamycin mouse lifespan extension study?

How does mTOR function and what are rapamycin's biological effects?

What are the differences in how rapamycin inhibits mTOR complexes?

How does the biochemical mechanism of rapamycin relate to its longevity benefit?

What is the interplay of amino acids and mTOR?

How does rapamycin affect muscle building and maintenance?

What is the tissue specificity of rapamycin?

Can rapamycin cross the blood-brain barrier and impact brain health?

Does rapamycin act as an immune modulator?

Can rapamycin reverse biological aging through T cell methylation patterns?

What are the side effects and mental health impacts of rapamycin?

How did rapamycin affect people who contracted COVID-19?

What would David like to study with mTOR inhibitors?

What are the studies of RTB101 and other ATP-competitive inhibitors of mTOR?

How does mTOR inhibition impact autophagy and inflammation?

What have we learned from the Dog Aging Project with rapamycin?

What are the preliminary results of primate studies with rapamycin?

What is the dosing of rapamycin?

How does rapamycin affect fertility?

What is the outlook for future research on rapamycin and rapalogs?

Shownotes Transcript

#272 ‒ Rapamycin: potential longevity benefits, surge in popularity, unanswered questions, and more | David Sabatini, M.D., Ph.D. and Matt Kaeberlein, Ph.D. 02:50:40 Share

The Peter Attia Drive

What are David and Matt's insights on mTOR and rapamycin?

How was rapamycin discovered and first used in humans?

Can rapamycin potentially prolong lifespan?

What were the findings of the rapamycin mouse lifespan extension study?

How does mTOR function and what are rapamycin's biological effects?

What are the differences in how rapamycin inhibits mTOR complexes?

How does the biochemical mechanism of rapamycin relate to its longevity benefit?

What is the interplay of amino acids and mTOR?

How does rapamycin affect muscle building and maintenance?

What is the tissue specificity of rapamycin?

Can rapamycin cross the blood-brain barrier and impact brain health?

Does rapamycin act as an immune modulator?

Can rapamycin reverse biological aging through T cell methylation patterns?

What are the side effects and mental health impacts of rapamycin?

How did rapamycin affect people who contracted COVID-19?

What would David like to study with mTOR inhibitors?

What are the studies of RTB101 and other ATP-competitive inhibitors of mTOR?

How does mTOR inhibition impact autophagy and inflammation?

What have we learned from the Dog Aging Project with rapamycin?

What are the preliminary results of primate studies with rapamycin?

What is the dosing of rapamycin?

How does rapamycin affect fertility?

What is the outlook for future research on rapamycin and rapalogs?

Shownotes Transcript

#272 ‒ Rapamycin: potential longevity benefits, surge in popularity, unanswered questions, and more | David Sabatini, M.D., Ph.D. and Matt Kaeberlein, Ph.D.