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#66 - Vamsi Mootha, M.D.: Aging, type 2 diabetes, cancer, Alzheimer’s disease, and Parkinson’s disease – do all roads lead to mitochondria?

2019/8/12

The Peter Attia Drive

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#66 - Vamsi Mootha, M.D.: Aging, type 2 diabetes, cancer, Alzheimer’s disease, and Parkinson’s disease – do all roads lead to mitochondria?

The Peter Attia Drive

The Broad Institute of MIT and Harvard

Vamsi’s academic background

Advice for aspiring medical professionals?

Vamsi’s focus on mitochondria and mitochondrial disorders

The mitochondrial genome: Lineage, endosymbiosis, and reductive evolution

How many diseases can be attributed to mitochondrial mutations?

Nuclear DNA and mtDNA: Roles, interaction, communication, and biogenesis

Which cells have the most mitochondrial DNA? And how often does mitochondria turn-over in a cell?

Does ALL of your mitochondrial DNA come from your mother?

Mitochondria 101: The powerhouse of the cell, electron transport chain, and the NADH/NAD ratio

NAD and NADH: Role in the mitochondria, decline of NAD levels with age, and what it means to age at a mitochondrial level

Mitochondrial diseases Vamsi studies in his lab

Mitochondria and oxygen: Poor oxygen utilization and excess oxygen contributes to the pathology seen in some of the rare mitogenic diseases

What VO2 max can tell us about mitochondrial function, insulin resistance, type 2 diabetes, and more

Can studying mitochondrial disease provide insights into the common forms of aging?

Could muscle cell inflammation (a signature of aging) be caused by mtDNA damage being confused as foreign bacteria?

Exercise and mitochondrial health: Is there an optimal exercise strategy to slow the aging process?

What autophagy means in the context of mitochondria

Metformin’s impact on exercise and lactate levels

How might metformin confer longevity benefits?

Hypoxia as a potential therapeutic option for mitochondrial disease

Cancer prevention and treatment: hyperbaric oxygen chambers, targeting single carbon metabolism of the mitochondria, and more

Chronic diseases have altered mitochondria: Evidence for mitochondrial dysfunction causing Parkinson’s disease

Why Vamsi is very optimistic about the possibility of targeting mitochondrial proteins as therapies

Is it theoretically possible to genetically engineer a better functioning mitochondria?

Vamsi’s fantasy experiment in an unconstrained world

Shownotes Transcript

#66 - Vamsi Mootha, M.D.: Aging, type 2 diabetes, cancer, Alzheimer’s disease, and Parkinson’s disease – do all roads lead to mitochondria? 02:27:53 Share

The Peter Attia Drive

The Broad Institute of MIT and Harvard

Vamsi’s academic background

Advice for aspiring medical professionals?

Vamsi’s focus on mitochondria and mitochondrial disorders

The mitochondrial genome: Lineage, endosymbiosis, and reductive evolution

How many diseases can be attributed to mitochondrial mutations?

Nuclear DNA and mtDNA: Roles, interaction, communication, and biogenesis

Which cells have the most mitochondrial DNA? And how often does mitochondria turn-over in a cell?

Does ALL of your mitochondrial DNA come from your mother?

Mitochondria 101: The powerhouse of the cell, electron transport chain, and the NADH/NAD ratio

NAD and NADH: Role in the mitochondria, decline of NAD levels with age, and what it means to age at a mitochondrial level

Mitochondrial diseases Vamsi studies in his lab

Mitochondria and oxygen: Poor oxygen utilization and excess oxygen contributes to the pathology seen in some of the rare mitogenic diseases

What VO2 max can tell us about mitochondrial function, insulin resistance, type 2 diabetes, and more

Can studying mitochondrial disease provide insights into the common forms of aging?

Could muscle cell inflammation (a signature of aging) be caused by mtDNA damage being confused as foreign bacteria?

Exercise and mitochondrial health: Is there an optimal exercise strategy to slow the aging process?

What autophagy means in the context of mitochondria

Metformin’s impact on exercise and lactate levels

How might metformin confer longevity benefits?

Hypoxia as a potential therapeutic option for mitochondrial disease

Cancer prevention and treatment: hyperbaric oxygen chambers, targeting single carbon metabolism of the mitochondria, and more

Chronic diseases have altered mitochondria: Evidence for mitochondrial dysfunction causing Parkinson’s disease

Why Vamsi is very optimistic about the possibility of targeting mitochondrial proteins as therapies

Is it theoretically possible to genetically engineer a better functioning mitochondria?

Vamsi’s fantasy experiment in an unconstrained world

Shownotes Transcript

#66 - Vamsi Mootha, M.D.: Aging, type 2 diabetes, cancer, Alzheimer’s disease, and Parkinson’s disease – do all roads lead to mitochondria?